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Endo, Akira
Isotope News, (781), P. 3, 2022/06
The research reactor JRR-3 at the Nuclear Science Research Institute of Japan Atomic Energy Agency resumed its operation in February 2021 for the first time in 10 years. After commissioning, neutron beam experimental apparatus and irradiation facilities were used from July to November, and the operation in 2021 was completed as planned. During this period, Ir-192 and Au-198 were produced and supplied for therapeutic use, and test irradiation for the production of Mo-99 was performed. This is resumption of radioisotope production using nuclear reactors in Japan, which had stopped after the Great East Japan Earthquake. This article introduces future efforts of radioisotope production for medical applications in JRR-3.
Hokama, Tomonori; Otoshi, Kazuki*; Kataoka, Noriaki*
Hoken Butsuri (Internet), 57(1), p.65 - 69, 2022/03
no abstracts in English
Cu and 
Cu via the Zn(n, p)Cu and 
Zn(n, np/d)Cu reactions using accelerator neutronsKawabata, Masako*; Motoishi, Shoji*; Ota, Akio*; Motomura, Arata*; Saeki, Hideya*; Tsukada, Kazuaki; Hashimoto, Shintaro; Iwamoto, Nobuyuki; Nagai, Yasuki*; Hashimoto, Kazuyuki*
Journal of Radioanalytical and Nuclear Chemistry, 330(3), p.913 - 922, 2021/12
Times Cited Count：7 Percentile：75.99(Chemistry, Analytical)Both Cu and Cu are promising radionuclides in nuclear medicine. Production yields of these radionuclides were quantified by irradiating 55.4 g of natural zinc with accelerator neutrons. Clinically suitable Cu and Cu yields were estimated by experimental based numerical simulations using 100 g of enriched Zn and Zn, respectively, and elevated neutron fluxes from 40 MeV, 2 mA deuterons. A combined thermal- and resin-separation method was developed to isolate Cu and Cu from zinc, resulting in 73% separation efficiency and 97% zinc recovery. Such methods can provide large scale production of Cu and Cu for clinical applications.
Benu, D. P.*; Earnshaw, J.*; Ashok, A.*; Tsuchiya, Kunihiko; Saptiama, I.*; Yuliarto, B.*; Suendo, V.*; Mukti, R. R.*; Fukumitsu, Nobuyoshi*; Ariga, Katsuhiko*; et al.
Bulletin of the Chemical Society of Japan, 94(2), p.502 - 507, 2021/02
Times Cited Count：11 Percentile：65.6(Chemistry, Multidisciplinary)no abstracts in English
Mo yield using large sample mass of MoO
for sustainable production of MoTsukada, Kazuaki; Nagai, Yasuki*; Hashimoto, Kazuyuki*; Kawabata, Masako*; Minato, Futoshi; Saeki, Hideya*; Motoishi, Shoji*; Ito, Masatoshi*
Journal of the Physical Society of Japan, 87(4), p.043201_1 - 043201_5, 2018/04
Times Cited Count：10 Percentile：59.94(Physics, Multidisciplinary)Cu suitable for both cancer diagnosis and therapyNagai, Yasuki*; Tsukada, Kazuaki
Isotope News, (753), p.28 - 32, 2017/10
no abstracts in English
Watanabe, Yukinobu*; Kin, Tadahiro*; Araki, Shohei*; Nakayama, Shinsuke; Iwamoto, Osamu
EPJ Web of Conferences, 146, p.03006_1 - 03006_6, 2017/09
Times Cited Count：2 Percentile：77.83(Nuclear Science & Technology)The design of 
neutron sources requires comprehensive nuclear data of deuteron-induced reactions. Therefore, we have launched a research project on deuteron nuclear data, which is composed of measurements, theoretical model code development, cross section evaluation, and application to production of radioisotopes for medical use. Our goal is to develop a state-of-art deuteron nuclear data library up to 200 MeV necessary for the design of accelerator neutron sources with deuteron beam. The present status is reported in the presentation.
Cu produced by Zn(
)Cu to biodistribution study in tumor-bearing miceSugo, Yumi*; Hashimoto, Kazuyuki*; Kawabata, Masako*; Saeki, Hideya*; Sato, Shunichi*; Tsukada, Kazuaki; Nagai, Yasuki*
Journal of the Physical Society of Japan, 86(2), p.023201_1 - 023201_3, 2017/02
Times Cited Count：14 Percentile：67.84(Physics, Multidisciplinary)Cu produced by the Zn()Cu reaction was used for the first time to determine the biodistribution of CuCl
in colorectal tumor-bearing mice. High uptake of Cu was observed in the tumor as well as in the liver and kidney which are the major organs for copper metabolism. The result showing Cu accumulation in the tumor suggests that CuCl can be a potential radionuclide agent for cancer radiotherapy. It would also encourage further studies on the therapeutic effect in small animals using an increased dose of Cu produced by the Zn()Cu reaction using intense neutrons available at present.
Naito, Fujio*; Anami, Shozo*; Ikegami, Kiyoshi*; Uota, Masahiko*; Ouchi, Toshikatsu*; Onishi, Takahiro*; Oba, Toshiyuki*; Obina, Takashi*; Kawamura, Masato*; Kumada, Hiroaki*; et al.
Proceedings of 13th Annual Meeting of Particle Accelerator Society of Japan (Internet), p.1244 - 1246, 2016/11
The proton linac installed in the Ibaraki Neutron Medical Research Center is used for production of the intense neutron flux for the Boron Neutron Capture Therapy (BNCT). The linac consists of the 3-MeV RFQ and the 8-MeV DTL. Design average beam current is 10mA. Target is made of Beryllium. First neutron production from the Beryllium target was observed at the end of 2015 with the low intensity beam as a demonstration. After the observation of neutron production, a lot of improvement s was carried out in order to increase the proton beam intensity for the real beam commissioning. The beam commissioning has been started on May 2016. The status of the commissioning is summarized in this report.
Inoue, Tomio*; Hayakawa, Kazushige*; Shiotari, Harutaka*; Takada, Eiichi*; Torikoshi, Masami*; Nagasawa, Kiyoshi*; Hagiwara, Kazuo*; Yanagisawa, Kazuaki
Journal of Nuclear Science and Technology, 39(10), p.1114 - 1119, 2002/10
Times Cited Count：4 Percentile：29.2(Nuclear Science & Technology)no abstracts in English
Matsumura, Akira*; Yamamoto, Tetsuya*; Shibata, Yasushi*; Nakai, Kei*; Zhang, T.*; Akutsu, Hiroyoshi*; Matsushita, Akira*; Yasuda, Susumu*; Takano, Shingo*; Nose, Tadao*; et al.
Posuto Shikuensu Jidai Ni Okeru Noshuyo No Kenkyu To Chiryo, p.427 - 435, 2002/07
no abstracts in English
Kume, Tamikazu
Proceedings of 24th JAIF-KAIF Seminar on Nuclear Industry, p.RI_1_1 - RI_1_12, 2002/00
no abstracts in English
Yanagisawa, Kazuaki
Genshiryoku Hyakka Jiten ATOMICA (Internet), 4 Pages, 2001/00
no abstracts in English
Yanagisawa, Kazuaki; Kume, Tamikazu; Makuuchi, Keizo; Takeshita, Hidefumi
Hoshasen To Sangyo, (88), p.46 - 53, 2000/12
no abstracts in English
Torii, Yoshiya; Yamamoto, Kazuyoshi; Kishi, Toshiaki*; Hori, Naohiko; Kumada, Hiroaki; Horiguchi, Yoji
Proceedings of 9th International Symposium on Neutron Capture Therapy for Cancer, p.241 - 242, 2000/10
no abstracts in English
Yanagisawa, Kazuaki; Kume, Tamikazu; Makuuchi, Keizo; Takeshita, Hidefumi
Genshiryoku eye, 46(8), p.62 - 68, 2000/08
no abstracts in English
Tanaka, Ryuichi*
Genshiryoku Shisutemu Nyusu, 11(1), p.14 - 20, 2000/06
no abstracts in English
Tanaka, Ryuichi*; Yanagisawa, Kazuaki
Hoshasen Kyoiku, 3(1), p.51 - 57, 1999/00
no abstracts in English
Yamaguchi, Yasuhiro
Hoken Butsuri, 33(3), p.253 - 254, 1998/09
no abstracts in English
Enerugi Foramu, 43(516), P. 137, 1997/12
no abstracts in English
